| Date/Time | Event & Venue/City | |
| Sep 18, 2021 Sat 6:10PM |
Houston Astros vs. Arizona Diamondbacks | |
| Sep 19, 2021 Sun 1:10PM |
Houston Astros vs. Arizona Diamondbacks | |
| Sep 28, 2021 Tue 7:10PM |
Houston Astros vs. Tampa Bay Rays | |
| Sep 29, 2021 Wed 7:10PM |
Houston Astros vs. Tampa Bay Rays | |
| Sep 30, 2021 Thu 6:10PM |
Houston Astros vs. Tampa Bay Rays | |
| Oct 1, 2021 Fri 7:10PM |
Houston Astros vs. Oakland Athletics | |
| Oct 2, 2021 Sat 6:10PM |
Houston Astros vs. Oakland Athletics | |
| Oct 3, 2021 Sun 2:10PM |
Houston Astros vs. Oakland Athletics |