| Date/Time | Event & Venue/City | |
| Aug 26, 2021 Thu 1:05PM |
Buffalo Bisons vs. Worcester Red Sox | |
| Aug 27, 2021 Fri 7:05PM |
Buffalo Bisons vs. Worcester Red Sox | |
| Aug 28, 2021 Sat 6:05PM |
Buffalo Bisons vs. Worcester Red Sox | |
| Aug 29, 2021 Sun 1:05PM |
Buffalo Bisons vs. Worcester Red Sox | |
| Sep 7, 2021 Tue 6:05PM |
Buffalo Bisons vs. Syracuse Mets | |
| Sep 8, 2021 Wed 6:05PM |
Buffalo Bisons vs. Syracuse Mets | |
| Sep 9, 2021 Thu 6:05PM |
Buffalo Bisons vs. Syracuse Mets | |
| Sep 10, 2021 Fri 6:05PM |
Buffalo Bisons vs. Syracuse Mets | |
| Sep 11, 2021 Sat 6:05PM |
Buffalo Bisons vs. Syracuse Mets | |
| Sep 12, 2021 Sun 1:05PM |
Buffalo Bisons vs. Syracuse Mets | |
| Apr 17, 2070 Thu TBA |
Buffalo Bisons vs. Rochester Red Wings | |
| Apr 18, 2070 Fri TBA |
Buffalo Bisons vs. Rochester Red Wings | |
| Apr 19, 2070 Sat TBA |
Buffalo Bisons vs. Rochester Red Wings | |
| Apr 20, 2070 Sun TBA |
Buffalo Bisons vs. Scranton Wilkes-Barre RailRiders | |
| Apr 21, 2070 Mon TBA |
Buffalo Bisons vs. Scranton Wilkes-Barre RailRiders | |
| Apr 22, 2070 Tue TBA |
Buffalo Bisons vs. Scranton Wilkes-Barre RailRiders |