| Date/Time | Event & Venue/City | |
| May 5, 2021 Wed TBA |
Jersey Shore BlueClaws vs. Hudson Valley Renegades | |
| May 5, 2021 Wed TBA |
Tulsa Drillers vs. Amarillo Sod Poodles | |
| May 5, 2021 Wed TBA |
Greenville Drive vs. Bowling Green Hot Rods | |
| May 5, 2021 Wed TBA |
Cedar Rapids Kernels vs. Peoria Chiefs | |
| May 5, 2021 Wed TBA |
Tampa Tarpons vs. Dunedin Blue Jays | |
| May 5, 2021 Wed TBA |
Asheville Tourists vs. Brooklyn Cyclones | |
| May 5, 2021 Wed 8:00AM |
Wells Fargo Championship - Practice Round | |
| May 5, 2021 Wed 12:05PM |
Omaha Storm Chasers vs. St. Paul Saints | |
| May 5, 2021 Wed 12:40PM |
Seattle Mariners vs. Baltimore Orioles | |
| May 5, 2021 Wed 1:05PM |
Jacksonville Jumbo Shrimp vs. Norfolk Tides | |
| May 5, 2021 Wed 1:10PM |
Colorado Rockies vs. San Francisco Giants | |
| May 5, 2021 Wed 5:10PM |
San Diego Padres vs. Pittsburgh Pirates | |
| May 5, 2021 Wed 6:00PM |
Mercer Bears vs. Kennesaw State Owls | |
| May 5, 2021 Wed 6:00PM |
Jackson State Tigers vs. Louisiana-Monroe Warhawks | |
| May 5, 2021 Wed 6:05PM |
Buffalo Bisons vs. Worcester Red Sox | |
| May 5, 2021 Wed 6:35PM |
Wisconsin Timber Rattlers vs. Beloit Snappers | |
| May 5, 2021 Wed 6:38PM |
Los Angeles Angels of Anaheim vs. Tampa Bay Rays | |
| May 5, 2021 Wed 6:38PM |
Iowa Cubs vs. Indianapolis Indians | |
| May 5, 2021 Wed 6:40PM |
Minnesota Twins vs. Texas Rangers | |
| May 5, 2021 Wed 6:40PM |
Cincinnati Reds vs. Chicago White Sox | |
| May 5, 2021 Wed 6:40PM |
Miami Marlins vs. Arizona Diamondbacks | |
| May 5, 2021 Wed 6:40PM |
Minnesota Twins vs. Texas Rangers | |
| May 5, 2021 Wed 6:40PM |
Oakland Athletics vs. Toronto Blue Jays | |
| May 5, 2021 Wed 6:40PM |
Miami Marlins vs. Arizona Diamondbacks | |
| May 5, 2021 Wed 6:40PM |
Chicago Cubs vs. Los Angeles Dodgers |