| Date/Time | Event & Venue/City | |
| Apr 4, 2021 Sun 1:20PM |
Chicago Cubs vs. Pittsburgh Pirates | |
| Apr 4, 2021 Sun 5:37PM |
Los Angeles Angels of Anaheim vs. Chicago White Sox | |
| Apr 4, 2021 Sun 5:37PM |
Los Angeles Angels of Anaheim vs. Chicago White Sox | |
| Apr 5, 2021 Mon 1:10PM |
Detroit Tigers vs. Minnesota Twins | |
| Apr 5, 2021 Mon 3:05PM |
Texas Rangers vs. Toronto Blue Jays - Home Opener | |
| Apr 5, 2021 Mon 4:05PM |
Washington Nationals vs. Atlanta Braves | |
| Apr 5, 2021 Mon 4:10PM |
Cleveland Indians vs. Kansas City Royals - Home Opener | |
| Apr 5, 2021 Mon 6:35PM |
New York Yankees vs. Baltimore Orioles | |
| Apr 5, 2021 Mon 6:38PM |
Los Angeles Angels of Anaheim vs. Houston Astros | |
| Apr 5, 2021 Mon 6:38PM |
Los Angeles Angels of Anaheim vs. Houston Astros | |
| Apr 5, 2021 Mon 6:40PM |
Cincinnati Reds vs. Pittsburgh Pirates | |
| Apr 5, 2021 Mon 6:40PM |
Miami Marlins vs. St. Louis Cardinals | |
| Apr 5, 2021 Mon 6:40PM |
Chicago Cubs vs. Milwaukee Brewers | |
| Apr 5, 2021 Mon 6:40PM |
Oakland Athletics vs. Los Angeles Dodgers | |
| Apr 5, 2021 Mon 6:40PM |
Miami Marlins vs. St. Louis Cardinals | |
| Apr 5, 2021 Mon 6:40PM |
Chicago Cubs vs. Milwaukee Brewers | |
| Apr 5, 2021 Mon 6:40PM |
Cincinnati Reds vs. Pittsburgh Pirates | |
| Apr 5, 2021 Mon 7:05PM |
Philadelphia Phillies vs. New York Mets | |
| Apr 5, 2021 Mon 7:05PM |
Philadelphia Phillies vs. New York Mets | |
| Apr 5, 2021 Mon 7:10PM |
Seattle Mariners vs. Chicago White Sox | |
| Apr 5, 2021 Mon 7:10PM |
Seattle Mariners vs. Chicago White Sox | |
| Apr 5, 2021 Mon 7:10PM |
San Diego Padres vs. San Francisco Giants | |
| Apr 5, 2021 Mon 7:10PM |
Boston Red Sox vs. Tampa Bay Rays | |
| Apr 5, 2021 Mon 7:10PM |
Boston Red Sox vs. Tampa Bay Rays | |
| Apr 6, 2021 Tue 1:07PM |
Los Angeles Angels of Anaheim vs. Houston Astros |